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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MYO1C All Species: 9.09
Human Site: S583 Identified Species: 16.67
UniProt: O00159 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.25
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O00159 NP_001074248.1 1063 121724 S583 S S K N P I M S Q C F D R S E
Chimpanzee Pan troglodytes XP_001174155 1044 119627 S581 S S K N P I M S Q C F D R S E
Rhesus Macaque Macaca mulatta XP_001117297 943 107150 L509 L G R G E F R L L H Y A G E V
Dog Lupus familis XP_537765 1636 184093 S712 S S E N P I M S Q C F D R S E
Cat Felis silvestris
Mouse Mus musculus Q9WTI7 1063 121926 A583 S S M N P I M A Q C F D K S E
Rat Rattus norvegicus Q63355 1044 119793 A564 S S T N P I M A Q C F D K S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508359 1162 132441 K601 S S K N G I V K E C F L T T E
Chicken Gallus gallus Q5ZLA6 1028 118889 K560 R T E L T D K K R P E T A A T
Frog Xenopus laevis A0MP03 1028 118817 K560 R T E L T D K K R P E T V A T
Zebra Danio Brachydanio rerio A5PF48 1026 118045 E562 L M D Q R R P E T A A T Q F K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q23979 1035 118971 L561 N C F P E K E L R S L K R P E
Honey Bee Apis mellifera XP_394436 1060 122678 K575 H T T N S I I K N V F D V K D
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SDM3 1235 136290 L571 L F P Q Q V D L D N R R Q P P
Conservation
Percent
Protein Identity: 100 95.6 84.2 63.2 N.A. 96.9 95 N.A. 56.6 80.1 75.2 65.9 N.A. 50.7 52.1 N.A. N.A.
Protein Similarity: 100 96.2 85.2 64.1 N.A. 98.8 96.9 N.A. 71.3 89.4 86.6 81.1 N.A. 66.7 69.9 N.A. N.A.
P-Site Identity: 100 100 0 93.3 N.A. 80 80 N.A. 53.3 0 0 0 N.A. 13.3 26.6 N.A. N.A.
P-Site Similarity: 100 100 13.3 100 N.A. 93.3 93.3 N.A. 73.3 26.6 26.6 13.3 N.A. 26.6 46.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 31.7
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 48.9
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 16 0 8 8 8 8 16 0 % A
% Cys: 0 8 0 0 0 0 0 0 0 47 0 0 0 0 0 % C
% Asp: 0 0 8 0 0 16 8 0 8 0 0 47 0 0 8 % D
% Glu: 0 0 24 0 16 0 8 8 8 0 16 0 0 8 54 % E
% Phe: 0 8 8 0 0 8 0 0 0 0 54 0 0 8 0 % F
% Gly: 0 8 0 8 8 0 0 0 0 0 0 0 8 0 0 % G
% His: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 54 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 24 0 0 8 16 31 0 0 0 8 16 8 8 % K
% Leu: 24 0 0 16 0 0 0 24 8 0 8 8 0 0 0 % L
% Met: 0 8 8 0 0 0 39 0 0 0 0 0 0 0 0 % M
% Asn: 8 0 0 54 0 0 0 0 8 8 0 0 0 0 0 % N
% Pro: 0 0 8 8 39 0 8 0 0 16 0 0 0 16 8 % P
% Gln: 0 0 0 16 8 0 0 0 39 0 0 0 16 0 0 % Q
% Arg: 16 0 8 0 8 8 8 0 24 0 8 8 31 0 0 % R
% Ser: 47 47 0 0 8 0 0 24 0 8 0 0 0 39 0 % S
% Thr: 0 24 16 0 16 0 0 0 8 0 0 24 8 8 16 % T
% Val: 0 0 0 0 0 8 8 0 0 8 0 0 16 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _